A ghrelin receptor (GHS-R1A) antagonist attenuates the rewarding properties of morphine and increases opioid peptide levels in reward areas in mice
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A ghrelin receptor (GHS-R1A) antagonist attenuates the rewarding properties of morphine and increases opioid peptide levels in reward areas in mice
Gut-brain hormones such as ghrelin have recently been suggested to have a role in reward regulation. Ghrelin was traditionally known to regulate food intake and body weight homoeostasis. In addition, recent work has pin-pointed that this peptide has a novel role in drug-induced reward, including morphine-induced increase in the extracellular levels of accumbal dopamine in rats. Herein the effec...
متن کاملGhrelin increases intake of rewarding food in rodents
We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of reward...
متن کاملSub-chronic Ghrelin Receptor Blockade Attenuates Alcohol- and Amphetamine-Induced Locomotor Stimulation in Mice.
AIMS Ghrelin initially emerged as a gut-brain hormone controlling food intake, meal initiation and appetite mainly via hypothalamic circuits in both rodents and humans. The findings that ghrelin receptors (GHS-R1A) are expressed in reward-related areas, including the nucleus accumbens (NAc) and ventral tegmental area (VTA), suggest that ghrelin is a novel reward regulator. Indeed, ghrelin signa...
متن کاملAccess to the Published Version May Require Subscription. Published with Permission From: Springer-verlag Ghrelin Receptor Antagonism Attenuates Cocaine-and Amphetamine-induced Locomotor Stimulation, Accumbal Dopamine Release and Conditioned Place Preference
This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. Ghrelin receptor antagonism attenuates cocaine-and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference. Abstract Recently we demonstrated that genetic or pharmacological suppression of the central ghrelin signalling system, involv...
متن کاملGrowth hormone-releasing hormone as an agonist of the ghrelin receptor GHS-R1a.
Ghrelin synergizes with growth hormone-releasing hormone (GHRH) to potentiate growth hormone (GH) response through a mechanism not yet fully characterized. This study was conducted to analyze the role of GHRH as a potential ligand of the ghrelin receptor, GHS-R1a. The results show that hGHRH(1-29)NH(2) (GHRH) induces a dose-dependent calcium mobilization in HEK 293 cells stably transfected with...
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ژورنال
عنوان ژورنال: European Neuropsychopharmacology
سال: 2015
ISSN: 0924-977X
DOI: 10.1016/j.euroneuro.2015.10.004